發表「中藥抗癌機轉論文」於第25屆生醫年會

圖：第二十五屆生物醫學年會海報

 

每年的三、四月間舉辦的的生物醫學聯合學術年會（以下簡稱生醫年會），是台灣學術界最重要的一場會議，只要從事生物醫學相關研究的人員，幾乎都曾參與過這個會議。今年的生醫年會，已經是第二十五屆了，於三月27、28（六、日）在台北國防醫學院舉辦，共計有1000餘篇的論文發表在這個會議中，而參加的人數更多達二、三千人，也因此台灣生物醫學各領域的菁英可以在這個會議中齊聚一堂，共同分享及交流研究中所遇到的問題。

圖：吳醫師於生物醫學年會入口處

研究論文獲選為「56屆美國骨科研究學會」年會論文

每年一度舉行的「美國骨科研究學會年會」是目前全世界骨科研究最重要的年度盛會，幾乎所有現代臨床醫學中關於「骨頭方面」的治療，都是在這個會議上首先被提出討論，經由全世界骨科醫師、研究人員的修正，最後才成為完整而成熟的治療方式。也因此參與這個會議的人員，幾乎都是由臨床醫師(MD)或是博士級(PhD)以上的研究人員參與，而論文能在這個會議中發表也代表研究成果被全世界肯定。

十分榮幸的，吳啟銘醫師的研究論文，今年再度被「56屆骨科研究學會年會」接受，並將在明年(99年)三月期間，遠赴美國新紐澳良參加這個年度盛會並發表研究成果，除了和世界的骨科研究菁英討論未來中醫藥發展方向外，吳醫師並將努力將最新臨床治療知識帶回台灣。以下是論文被接受函節略...

EA effects on OP

Study of the effects and mechanisms of electric stimulate acupoints induced bone mineral density changes.

Osteoporosis is a progressive bone disorder characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to increased bone fragility and susceptibility to fracture. Electrical stimulation for bone repair has been used for three decades and was approved by the Food and Drug Administration (FDA) for pseudarthrosis and bone nonunion. Mechanical or electrical stimuli of relative low amplitude and high frequency can influence bone formation and resorption in vitro and in vivo, suggesting that these modalities can be used clinically to inhibit or reverse osteopenia.

We hypothesized that electric stimulation for acupoints can induce bone mineral density (BMD) change in ovariectomized (OVX) rats. Twenty-four 6-week old SD female rats (BioLASCO Taiwan Co., Ltd.) weighing 180-220 g were used in this study. The rats were randomly divided into a control group (n=8), a sham group (n=8) and an electroacupuncture(EA) group (n=8). The acupuncture group were given acupuncture bilaterally at ST36 and SP6, 15mins per time, five times a week for 4 weeks (total 20 times), under isoflurane anesthesia (in flow of oxygen and nitrous oxide mixture; 3% for induction and 1.5% for maintenance). The positive electrode was connected to ST36, and the negative electrode to SP6. Electrical stimulation were provided by a pulse stimulator (Trio 300, Ito Co., Japan), which produced a biphasic square wave with the following characteristics: 2 Hz frequency, 2 mA duration pulses. The current intensity were adjusted until localized muscle contractions were observed.

Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, therapies involved in BMP activation are good ways for the development of anti-osteoporosis treatments. In this study, EA was shown to enhance serum alkaline phosphatase (ALP) and BMP-2 activity of OVX rats. EA also increased the bone volume of secondary spongiosa in tibia.
Taken together, our results provided the evidence that EA could increase BMP-2 and enhance bone formation in OVX rats.

【撰寫/臻品中醫診所╱吳啟銘醫師】

參與「第五十五屆美國骨科研究學會年度會議」並發表論文

前言：第五十五屆美國骨科研究學會年度會議(55th Annual Meeting of the Orthopaedic Research Society,以下簡稱ORS)今年在美國拉斯維加斯(LasVegas, Nevada)舉行，在本人指導教授馮逸卿教授(中國醫藥大學附設醫院骨科部)、李德茂教授（中國醫藥大學中醫學系）以及湯智昕教授（中國醫藥大學藥理學科）的細心指導下，筆者以題目”BMP-2 increases migration of humanchondrosarcoma cell via PI3K/Akt pathway”之論文在該研討會參展，並獲得國科會相關補助，感到甚為榮幸。


以下就ORS 的介紹以及大會議題及本人發表論文摘要及會後心得與建議分段敘述。